The situation report includes an update on the epidemiological situation for mpox in Africa, with data as of 20 July 2025, and the operational response updates as of 23 July 2025.
| Thursday, 31 July 2025 SITUATION REPORT Multi-country outbreak of mpox, External situation report #56 - 31 July 2025 https://www.who.int/publications/m/item/multi-country-outbreak-of-mpox--external-situation-report--56---31-july-2025 The 56th situation report for the multi-country outbreak of mpox provides details on the global epidemiological situation for mpox, and an update on the epidemiological situation for mpox in Africa (data as of 20 July 2025) and the operational response updates (as of 23 July 2025). Highlights: - All clades of monkeypox virus (MPXV) continue to circulate in several countries. When mpox outbreaks are not rapidly contained and human-to-human transmission is not interrupted, they continue to pose a risk of sustained community transmission.
- Since the last edition of this report, one new country, the Gambia, has reported an mpox case for the first time. Genomic sequencing analysis has identified clade IIb MPXV.
- Furthermore, Mozambique, has reported cases of mpox due to clade Ib MPXV for the first time.
- Twenty-one countries in Africa have reported ongoing mpox transmission in the past six weeks. Clade IIb MPXV continues to be reported in West Africa, while Central African countries report both clade Ia and clade Ib MPXV, and East African countries report clade Ib MPXV.
- The recent overall downward trend of confirmed cases across the continent is driven by the decline in cases in Sierra Leone and the Democratic Republic of the Congo.
- Uganda continues to experience community transmission of clade Ib MPXV, reporting the third-highest number of laboratory-confirmed cases in the continent. Cases continue to be reported primarily among young adults of both sexes, and 48% of deaths were among people living with HIV. The slight increase in weekly cases reported in the previous edition of this report appears to have been short-lived, with a downward trend reported in the most recent weeks.
- Australia, China and the United Kingdom have reported additional cases of mpox due to clade Ib MPXV since the last situation report. These cases have been linked to travel, and community transmission of clade Ib MPXV continues to be reported only in countries in central and Eastern Africa.
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