| No images? Click here  Monday, 22 September 2025 SITUATION REPORT Multi-country outbreak of mpox External situation report #58 - 19 September 2025 Overview This is the 58th situation report for the multi-country outbreak of mpox, which provides details on the global epidemiological situation for mpox, including an update on the epidemiological situation for mpox in Africa, with data on the global situation as of 31 August 2025, in Africa as of 14 September and the operational response updates as of 19 September 2025. Highlights Following the convening of the Emergency Committee under the provisions of the International Health Regulations (2005) on 4 September 2025, the WHO Director-General determined that the mpox multicountry outbreak no longer constitutes a public health emergency of international concern (PHEIC). • The lifting of the PHEIC does not mean the threat is over, and WHO’s response continues. Mpox continues to circulate, especially in Africa where over 90% of cases are reported, and flare-ups remain possible everywhere. Vulnerable groups, particularly children, pregnant women and people living with HIV, continue to face higher risks for severe disease and death. Surveillance, diagnostics, community engagement, and response capacity must therefore be maintained. • The rapid risk assessment of the overall public health risk posed by mpox was updated on 2 September 2025. The overall global public health risk was assessed as moderate. • All clades of the monkeypox virus (MPXV) continue to circulate. When mpox outbreaks are not rapidly contained and human-to-human transmission is not interrupted, they pose a risk of sustained community transmission. • Since the last edition of this report, one country, Kuwait, has reported mpox for the first time; genomic sequencing analysis identified clade IIb MPXV. Japan and Senegal have reported cases of mpox due to clade Ib MPXV for the first time. • In August 2025, 59 countries across all WHO regions reported a total of 3780 confirmed cases, including 15 deaths (case fatality ratio [CFR] 0.4%). The Eastern Mediterranean and European regions reported an increase in cases in August compared to July 2025, while the African Region, Region of the Americas, South-East Asia Region and Western Pacific Region reported a decrease. • Nineteen countries in Africa have reported active mpox transmission in the past six weeks. Clade IIb MPXV continues to be mostly reported in West Africa, Central African countries report both clade Ia and clade Ib MPXV, and East African countries report clade Ib MPXV. • Australia and Thailand have reported additional cases of mpox due to clade Ib MPXV since the last situation report. These cases have been linked to travel, and community transmission of clade Ib MPXV continues to only be reported in countries in central and eastern Africa Read the full report:  Media contacts:  You are receiving this NO-REPLY email because you are included on a WHO mail list.  |
Monday, September 22, 2025
SITUATION REPORT: Multi-country outbreak of mpox External situation report #58 - 19 September 2025
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